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| What is ncRNA ? |
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Traditionally, most RNA molecules were thought to function as mediators carrying the information from the gene to the translational machinery. The most prominent exceptions to this, were transfer RNA (tRNA) and ribosomal RNA (rRNA), both of which are involved in the process of translation. However, since the late 1990s, it has been widely acknowledged that other types of untranslated RNA molecules are present in many different organisms ranging from bacteria to mammals, and are affecting a large variety of processes including plasmid replication, phage development, chromosome structure, DNA transcription, RNA processing and modification, development control and more. These untranslated RNA molecules have been given a variety of names, the term small RNAs (sRNAs) predominantly used for bacterial RNAs while the term noncoding RNAs (ncRNAs) has been more common in eukaryotes. In order to have a common term for all such RNAs, we have opted to call all of these functional RNA noncoding RNAs (ncRNAs).
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